Noise Ninja custom noise print- worth the effort for stacked photo??

I am an amateur astronomer and use a digicam to take pictures of the solar
system. I take up to 100 photos and then stack the photos into one to
reduce noise levels. However, sometimes a 100 photo composite isn't enough
for the amount of noise I get. I have Noise Ninja, but don't use it much
because I am never happy with the results as it seems to smooth the images
too much, washing out details. However, I have never created a custom noise
print for my camera, using the checkerboard pattern and a defocused shot.
My big question is: would a custom noise print created this way be worth the
effort and would the results be better than just the box sampling I do now
from the existing image? Also, I'm guessing that I would need to take 100
such samples since 100 images make up a composite, but not sure how to go
about it. I would think that each image would have to have noise reduction
before stacking for this to work and that's how I was going to do it. So,
yes, a lot of effort involved, but would the result be worth it?

Thanks,
Jason Sommers